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Image Search Results
Journal: bioRxiv
Article Title: Non-canonical Sodium Channel Isoforms Underlie Chamber Specific Cardiac Excitability
doi: 10.1101/2025.08.27.672688
Figure Lengend Snippet: (A-H) Cardiac electrophysiology meters of WT (black, triangles) and NaV1.5-GX mice (orange, circles) after intraperitoneal (A-D) or oral (E-H) administration of GX-201. Heart (A, E), PR interval (B, F), QRS duration (C, G), and representative traces in lead modified V (D, H) were measured by ECG 1 hour after IP inistration and after 3 days of oral administration of GX-201. (I-J) Comparison of PR interval (I) and QRS duration (J) of WT (black, triangles) Nav1.5-GX mice (orange, circles) before and after 3 days of 2.5 mg/kg/day oral GX-201. (K-L) Kaplan-Meier curves of WT (black, triangles) aV1.5-GX (orange, circles) mice without bradyarrhythmia (K) or tachyarrhythmia (L) on ECG telemetry over 3 days of 2.5 mg/kg/day oral GX-Bradyarrhythmia status was defined as >2.5% of R-R intervals longer than the longest 1% of R-R intervals at baseline, and tachyarrhythmia us was defined as >0.5% of total R-R intervals shorter than the 0.1% shortest R-R intervals at baseline. (M-N) Example ECG traces of heart k (blue lines, M) and non-sustained ventricular tachycardia (VT, red lines, N) and after 5 mg/kg IP injection. Mean ± SD. Statistical significance rmined by two-way ANOVA (I-J) or log-rank test (K-L) at α=0.05 (*, p<0.05; **, p<0.01; ***, p<0.001, ****, p<0.0001). N>3 for all plots.
Article Snippet:
Techniques: Modification, Comparison, Injection